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Neural correlates of the DMT experience assessed with multivariate EEG | Scientific Reports.
Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT – a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7 male) recorded via multivariate EEG, and plot relationships between subjective experience, brain activity and drug plasma concentrations across time. Compared with placebo, DMT markedly reduced oscillatory power in the alpha and beta bands and robustly increased spontaneous signal diversity. Time-referenced and neurophenomenological analyses revealed close relationships between changes in various aspects of subjective experience and changes in brain activity. Importantly, the emergence of oscillatory activity within the delta and theta frequency bands was found to correlate with the peak of the experience – particularly its eyes-closed visual component. These findings highlight marked changes in oscillatory activity and signal diversity with DMT that parallel broad and specific components of the subjective experience, thus advancing our understanding of the neurobiological underpinnings of immersive states of consciousness.
Harvard LSD Research Draws National Attention | News | The Harvard Crimson.
The Harvard Psilocybin Project propelled Harvard to the center of national media attention when details of the project’s administration of hallucinogenic drugs to students were exposed in the spring of 1962.
Psilocybin Ð Summary of knowledge and new perspectives – ScienceDirect.
Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays given a lot of attention in the scientific community as a reseaÉ
Advanced brain imaging study hints at how DMT psychedelic alters perception of reality — ScienceDaily
Scientists have gleaned new insights into how psychedelics alter conscious experience via their action on brain activity.
Is there a common path to the psychedelic experience? — ScienceDaily
A study takes a closer look at the neurobiology of psychedelic experiences caused by nitrous oxide, ketamine and LSD.
Psychedelics Slip Past Cell Membranes When Treating Depression | The Scientist Magazine¨
The antidepressant properties of hallucinogenic drugs may stem from their ability to bind to intracellular serotonin receptors, a study suggests.
10 Celebrity Experiences With Psychedelics á Psychedelic Support
These celebrity experiences with psychedelics have impacted mental health, world perspectives, and the overall well-being of these icons.
Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study – PubMed
A single ibogaine treatment reduced opioid withdrawal symptoms and achieved opioid cessation or sustained reduced use in dependent individuals as measured over 12 months. Ibogaine’s legal availability in New Zealand may offer improved outcomes where legislation supports treatment providers to work c É
Treatment of opioid use disorder with ibogaine: detoxification and drug use outcomes – PubMed
Ibogaine was associated with substantive effects on opioid withdrawal symptoms and drug use in subjects for whom other treatments had been unsuccessful, and may provide a useful prototype for discovery and development of innovative pharmacotherapy of addiction.