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Esquire
2021-01-12

California moves closer to decriminalizing psychedelic drugs

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Are trees, rocks or rivers conscious? Your answer may change depending on what drugs you’ve taken

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Research Chemicals

These are some of the most common research chemicals pioneer chemists such as Alexander ‘Sasha’ Shulgin, Albert Hofmann, Darrell Lemaire, Nick Sand, David E. Nichols, including many others, have introduced to the world.These substances include: The 2C Series, 25I-NBOMe And 25C-NBOMe, Methoxetamine (MXE), & Piperazines.

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Psilocybin

Psilocybin mushrooms, commonly known as ‘magic mushrooms,’ are fungi that contain the psychoactive compounds psilocybin and psilocin. There are over 200 species of mushrooms that contain one or both chemicals, most of which belong to the Psilocybe genus.

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Mescaline

Mescaline is the parent compound of the phenethylamine family. It is one of the oldest known naturally occurring psychedelic substances and can be found in the San Pedro (Echinopsis pachanoi) and peyote (Lophophora williamsii) cacti. The ceremonial and ritual uses of these cacti date back thousands of years and originate from native tribes in Texas and New Mexico, including the Tonkawa and Mescalero tribes, among several others. Though these cacti are commonly used for spiritual enlightenment and ritualistic purposes, peyote in particular has been used by the Rar’muri peoples as a topical treatment for wounds and in long-distance endurance foot races.

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MDMA

MDMA is a synthetic drug that is chemically similar to both stimulants and psychedelics. It was originally created as a life-saving blood-clotting medicine, which was first synthesized in 1912 by Dr. Anton K’llisch for the German pharmaceutical company Merck. However, significant testing was not done until 1927, after chemist Max Oberlin determined that it could mimic adrenaline since the two compounds shared a similar structure. Unfortunately, testing was put on hold due to a rise in price of chemical precursors. MDMA was not revived again until the mid-1970s, when American psychopharmacologist Alexander ‘Sasha’ Shulgin, who discovered nearly 250 psychedelic drugs and was famously known as ‘the Godfather of Ecstasy,’ synthesized MDMA and tested it on himself. Impressed with the experience, Shulgin recommended it to therapists and psychiatrists, including psychotherapist Dr. Leo Zeff, who introduced it to over 4,000 patients. The work of Alexander ‘Sasha’ Shulgin cannot be understated as he was a brilliant organic chemist and truly fearless psychonaut who was able to theorize and synthesize these chemicals (built on the frameworks of tryptamines and phenethylamines) and experiment with them at low doses until a perception shift was achieved.

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LSD

Lysergic acid diethylamide, best known as LSD, is derived from a chemical found in rye ergot fungus. It was discovered in 1938 when Swiss chemist Albert Hofmann created LSD-25, his 25th ergot-based compound, in an attempt to stimulate the respiratory and circulatory systems. The effects LSD has on the central nervous system (CNS) were unknown until 1943, when he accidentally tested it on himself. This discovery led to a deeper understanding of the brain’s neurochemistry and helped therapists effectively treat a wide range of conditions. After his profound experience with the substance, it was tested and studied for its therapeutic benefits by psychologists, researchers, and scientists throughout the 1950s. During that time, LSD was prescribed to tens of thousands of patients and over 1,000 research papers were produced. By the height of the 60s and 70s counterculture movement, the substance became synonymous with hippies and social outcasts. In 1971, the US government declared LSD a Schedule I substance and effectively ended research and development for several decades.

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