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Hallucinogenic drugs in pre-Columbian Mesoamerican cultures – ScienceDirect
The archaeological, ethno-historical and ethnographic evidence of the use of hallucinogenic substances in Mesoamerica is reviewed.Hallucinogenic cactuÉ
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2,400 Year Old Mummy Had Breast Cancer Used Cannabis
A 2,400-year-old "Siberian Ice Maiden" may have used medical marijuana to treat her breast cancer.
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‘Magic Mushrooms’ Help Longtime Smokers ‘Quit – 09/11/2014
Johns Hopkins researchers report that a small number of longtime smokers who had failed many attempts to drop the habit did so after a carefully controlled and monitored use of...
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A brief history of psychedelic psychiatry | Neuroscience | The Guardian
In the 1950s a group of pioneering psychiatrists showed that hallucinogenic drugs had therapeutic potential, but the research was halted as part of the backlash against the hippy counterculture.
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Treating drug dependence with the aid of ibogaine: A retrospective study
Ibogaine is an alkaloid purported to be an effective drug dependence treatment. However, its efficacy has been hard to evaluate, partly because it is illegal in some countries. In such...
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Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells | PLOS ONE
The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation and...
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Safety and Efficacy of Lysergic Acid Diethylamide-Assisted P… : The Journal of Nervous and Mental Disease
lemented by two LSD-assisted psychotherapy sessions 2 to 3 weeks apart. The participants received either 200 _g of LSD (n = 8) or 20 _g of LSD with an open-label...
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Hallucinogen use predicts reduced recidivism among substance-involved offenders under community corrections supervision
Hallucinogen-based interventions may benefit substance use populations, but contemporary data informing the impact of hallucinogens on addictive behavior are scarce. Given that many individuals in the criminal justice system engage...
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Marijuana: Current Concepts – PMC
Marijuana (cannabis) remains a controversial drug in the twenty-first century. This paper considers current research on use of Cannabis sativa and its constituents such as the cannabinoids. Topics reviewed include...
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Acid test: LSD wonÕt make you crazy Ð The Mail & Guardian
LSD may be classed as an illegal narcotic by the SAPS, but a recent study has shown its effects might be more helpful than harmful.
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Large study concludes LSD and other psychedelics reduce risk of mental health problems
The use of LSD, magic mushrooms, or peyote does not increase a person's risk of developing mental health problems. ...
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LSD and other psychedelics not linked with mental health problems, analysis suggests — ScienceDaily
The use of LSD, magic mushrooms, or peyote does not increase a personÕs risk of developing mental health problems, according to an analysis of information from more than 130,000 randomly...
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Scientists Think Cavemen Painted While High on Hallucinogenic Drugs
There's something undeniably surreal about early cave paintings, something otherworldly or even psychedelic. And according to a team of international scientists, that's because the cave painters were doing mind-bending drugs...
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Harvard LSD Research Draws National Attention | News | The Harvard Crimson.
The Harvard Psilocybin Project propelled Harvard to the center of national media attention when details of the project's administration of hallucinogenic drugs to students were exposed in the spring of...
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Should we use LSD to treat alcoholism? | The Week
A new look at the old practice of giving LSD to alcoholics suggests the trippy treatment deserves a second chance
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The Return on Investment of a Medicaid Tobacco Cessation Program in Massachusetts | PLOS ONE
Background and Objective A high proportion of low-income people insured by the Medicaid program smoke. Earlier research concerning a comprehensive tobacco cessation program implemented by the state of Massachusetts indicated...
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Cannabis Science Publishes List of Over 800 Peer-Reviewed Cannabis and Cancer References From Scientists Around the World
Cannabis Science, Inc. (OTCBB:CBIS) a pioneering US biotech company developing pharmaceutical cannabis products, as part of our public education mission, is pleased to release a growing list of peer-reviewed, cannabis...
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Mystical Experiences Occasioned by the Hallucinogen Psilocybin Lead to Increases in the Personality Domain of Openness – PMC
A large body of evidence, including longitudinal analyses of personality change, suggests that core personality traits are predominantly stable after age 30. To our knowledge, no study has demonstrated changes...
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Cannabis and Its Derivatives: Review of Medical Use | American Board of Family Medicine
Background: Use of cannabis is often an under-reported activity in our society. Despite legal restriction, cannabis is often used to relieve chronic and neuropathic pain, and it carries psychotropic and...
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Brains of Buddhist monks scanned in meditation study – BBC News
The BBC's Matt Danzico reports on a US neuroscientist who is scanning the brains of Buddhist monks in the hopes of understanding the science behind tranquillity.
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Psilocybin Ð Summary of knowledge and new perspectives – ScienceDire ...
Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays given a lot of attention in the scientific community as a reseaÉ
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Psilocybe Cubensis and Other Types of Magic Mushrooms You Should Know ̵ ...
Magic mushrooms are so incredible and mysterious, from the beautiful experiences they occasion to the mystical compounds that they naturally produce. But
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Psilocybin Treatment for Major Depression Effective for Up to a Year for Mo ...
Previous studies by Johns Hopkins Medicine researchers showed that psychedelic treatment with psilocybin relieved major depressive disorder symptoms in adults for up to a month. Now, in a follow-up study of those participants, the researchers report that the substantial antidepressant effects of psilocybin-assisted therapy, given with supportive psychotherapy, may last at least a year for some patients.
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Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DM ...
N,N-dimethyltryptamine (DMT), a psychedelic compound identified endogenously in mammals, is biosynthesized by aromatic-L-amino acid decarboxylase (AADC) and indolethylamine-N-methyltransferase (INMT). Whether DMT is biosynthesized in the mammalian brain is unknown. We investigated brain expression of INMT transcript in rats and humans, co-expression of INMT and AADC mRNA in rat brain and periphery, and brain concentrations of DMT in rats. INMT transcripts were identified in the cerebral cortex, pineal gland, and choroid plexus of both rats and humans via in situ hybridization. Notably, INMT mRNA was colocalized with AADC transcript in rat brain tissues, in contrast to rat peripheral tissues where there existed little overlapping expression of INMT with AADC transcripts. Additionally, extracellular concentrations of DMT in the cerebral cortex of normal behaving rats, with or without the pineal gland, were similar to those of canonical monoamine neurotransmitters including serotonin. A significant increase of DMT levels in the rat visual cortex was observed following induction of experimental cardiac arrest, a finding independent of an intact pineal gland. These results show for the first time that the rat brain is capable of synthesizing and releasing DMT at concentrations comparable to known monoamine neurotransmitters and raise the possibility that this phenomenon may occur similarly in human brains.
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Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-S ...
Researchers conducted extensive investigations of hallucinogens in the 1950s and 1960s. By the early 1970s, however, political and cultural pressures forced the cessation of all projects. This investigation reexamines a potentially promising clinical application of hallucinogens in the…
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Psilocybin Treatment for Major Depression Effective for Up to a Year for Mo ...
Previous studies by Johns Hopkins Medicine researchers showed that psychedelic treatment with psilocybin relieved major depressive disorder symptoms in adults for up to a month. Now, in a follow-up study of those participants, the researchers report that the substantial antidepressant effects of psilocybin-assisted therapy, given with supportive psychotherapy, may last at least a year for some patients.
Read More
Psilocybin Ð Summary of knowledge and new perspectives – ScienceDire ...
Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays given a lot of attention in the scientific community as a reseaÉ
Read More
Psilocybe Cubensis and Other Types of Magic Mushrooms You Should Know ̵ ...
Magic mushrooms are so incredible and mysterious, from the beautiful experiences they occasion to the mystical compounds that they naturally produce. But
Read More
Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DM ...
N,N-dimethyltryptamine (DMT), a psychedelic compound identified endogenously in mammals, is biosynthesized by aromatic-L-amino acid decarboxylase (AADC) and indolethylamine-N-methyltransferase (INMT). Whether DMT is biosynthesized in the mammalian brain is unknown. We investigated brain expression of INMT transcript in rats and humans, co-expression of INMT and AADC mRNA in rat brain and periphery, and brain concentrations of DMT in rats. INMT transcripts were identified in the cerebral cortex, pineal gland, and choroid plexus of both rats and humans via in situ hybridization. Notably, INMT mRNA was colocalized with AADC transcript in rat brain tissues, in contrast to rat peripheral tissues where there existed little overlapping expression of INMT with AADC transcripts. Additionally, extracellular concentrations of DMT in the cerebral cortex of normal behaving rats, with or without the pineal gland, were similar to those of canonical monoamine neurotransmitters including serotonin. A significant increase of DMT levels in the rat visual cortex was observed following induction of experimental cardiac arrest, a finding independent of an intact pineal gland. These results show for the first time that the rat brain is capable of synthesizing and releasing DMT at concentrations comparable to known monoamine neurotransmitters and raise the possibility that this phenomenon may occur similarly in human brains.
Read More
Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-S ...
Researchers conducted extensive investigations of hallucinogens in the 1950s and 1960s. By the early 1970s, however, political and cultural pressures forced the cessation of all projects. This investigation reexamines a potentially promising clinical application of hallucinogens in the…
Read More
Popular News
Academic Centers Start to Take Psychedelics Seriously | MedPage Today
'You're not sticking your neck out as much as you would 10 years ago,' one director says Read More
Mechanisms and molecular targets surrounding the potential therapeutic effe ...
Psychedelics, also known as classical hallucinogens, have been investigated for decades due to their potential therapeutic effects in the treatment... Read More
How Does Love Work in Therapy? | Psychology Today Canada
A roundtable discussion with mental health researchers and practitioners. Read More
The oldest archeological data evidencing the relationship of Homo sapiens w ...
Modern sophisticated archeometric instruments are increasingly capable of detecting the presence of psychoactive plant sources in archeological contexts, testifying the... Read More
Can Psilocybin Stimulate Neurogenesis in the Hippocampus? | Psychology Toda ...
Hippocampal neurogenesis may play a role in psilocybin's antidepressant action. Read More
As Scientific Evidence Base for Safety, Efficacy of Ayahuasca Use Grows, a ...
Following an increase in government seizures of ayahuasca, an Indigenous religious organization requested government records that led to these seizures.... Read More